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Human chorionic gonadotropin immunoradiometric assay kit

Human chorionic gonadotropin immunoradiometric assay kit RIA

The OCPM03-HCG is an immunoradiometric assay of hCG for the detection and monitoring of pregnancie and tumors secreting hCG.

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The OCPM03-HCG is an immunoradiometric assay of hCG for the detection and monitoring of pregnancie and tumors secreting hCG.

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Overview

Pregnancy test

Monitor patients after a miscarriage or an abortion

Diagnose gestational trophoblastic disease (GTD), testicular tumors, ovarian germ cell tumors, teratomas, and, rarely, other hCG-secreting tumors

Monitor the therapeutic response in GTD or in hCG-secreting tumors Detect persistent or recurrent GTD or hCG-secreting tumors

Benefits

ASSAY STANDARDIZED AGAINST THE 1ST IRP (WHO 75/537)
BROAD MEASUREMENT RANGE

Assay principle: sandwich

Two anti-hCG monoclonal antibodies are used for the sandwich. The first monoclonal anti-ß-hCG antibody is adsorbed onto the tube walls. The second monoclonal anti-a-hCG antibody is radiolabeled with iodine-125.

Two alternative assay procedures:

1- Qualitative hCG assay: 10 min at RT / shaking + 10 min at RT / shaking

2- Quantitative hCG assay: 30 min at RT+ 60 min at RT

Features

Working range: 1 – 1000 mIU/mL 1st IRP (WHO 75/537).

Sample: serum or plasma – 100 µL

Analytical sensitivity: 1 mIU/mL

Normal values: pregnancy

Current weeks of gestation	n	Median (hCG mIU/mL)	Range (hCG mIU/mL)
Non pregnant	96	0
5	42	480	60 - 7100
5 - 6	105	2300	110 - 16 200
6 - 7	115	8400	530 – 62 200
7 - 8	81	30 700	3 000 – 130 000
8 - 9	69	82 700	17 800 – 207 400
9 - 10	69	121 500	30 600 – 254 600
10 - 11	53	121 600	34 400 – 244 800
11 - 12	46	97 300	29 100 – 213 300
12 - 13	35	67 650	25 900 – 208 400
13 - 14	28	71 100	30 600 – 189 000
2nd quarter	92	27 500	10 100 – 92 200
3rd quarter	34	15 200	3 360 – 43 500